When performing an examination on a suspected mast cell disorder patient, a basic physical screening for other conditions, common comorbidities, and some (possible) symptoms is recommended. Evaluate and note any anomalies in:

Lungs

Heart (Murmurs or any EDS or other connective tissue symptoms may merit a screening by qualified cardiologist. Recommend contrast-free echocardiagram to evaluate changes, particularly aortic aneurysm)

Lymph nodes

Arteries (palpable cholesterol deposits)

Skin involvement (Should the patient present with apparent spots or mastocytomas, biopsies may support a cutaneous mastocytosis diagnosis) or EDS symptoms.

Abdominal area (palpable hepatomegaly, palpable splenomegaly)

Thyroid

Presence of dermatographia

Appearance of Ehler Danlos (See Beighton scale, in conjunction with patient history, and note also joints in which notably tight or inflexible muscles may be overcompensating for unstable joints.)

Postural blood pressure changes and POTS (blood pressure and pulse. Diagnosis of POTS requires a heart rate increase of 30 beats per minute or more or reaching over 120 beats per minute shortly after moving from a supine position to standing. Note that POTS may only present in some subset of mast cell reactions secondary to a mast cell disorder.)

See symptoms for information on evaluating a patient's medical history.